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It is important to observe that the preventive effect is stronger when the intervention starts earlier in pregnancy [ 68, 69].
Second, the remaining Quality-Adjusted Life Expectancy without the new intervention (QALEstd, the starting point of QALEstd is the time when the intervention starts (T)), and the ending point is the time of death without the new intervention).
As previously described by Harrison et al. [ 16], a distinguishing feature of eRapa is its ability to extend median and maximum life when the intervention starts at a relatively old age (600 days) in mice.
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We included ITSs with a defined point in time when the intervention started and at least three data points before and three after the intervention.
To estimate caesarean section rates prior to intervention, we used the data of women who were past 32 weeks when the intervention started, and thus unlikely to get the new childbirth education.
This is exacerbated by the fact that the children who filled in the questionnaire at the second timepoint were at an advantage when the intervention started, and, therefore, a selection bias influencing the results must be assumed.
The intervention starts at the diabetes nurse.
The intervention starts after baseline measurements.
The intervention starts at 36 weeks.
34 Sharing picture books is one of the main topics of the programme, since picture book sharing is an ideal time to initiate communication as well as being a prototypical situation for learning words at the age of 2. 24 The intervention started when the children were about 25 months old.
When the intervention was started in the first trimester (average of 9 wk gestational age), the beneficial effects on birth weight and even on offspring mortality were significantly greater than when the same intervention was commenced at 20 wk.
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