When not fully functional replicators are viable (i.e. selection is based on functionality instead of replication), replicators can suffice with lower functionality under increased mutation rates.
Thus, the growth retardation phenotype is shared between human and mouse when FTO is not functional, indicating a primary function of FTO in the regulation of linear growth.
Interestingly, though, we found that the period and phase of Per1-luc expression in the pituitary and lung were altered when PER3 was not functional.
Techniques have been described that allow NIBS to be targeted using generic MRI datasets [ 21] or when structural but not functional MRI data are available for individual participants [ 22].
Despite this relatively small quantity of SWS cones, humans can readily detect short wavelengths of light, and when SWS is not functional or absent (i.e., tritanopia, or 'blue-yellow color blindness') the effect on color discrimination is often dramatic (reviewed by Bowmaker [ 73, 74]).
It's better to just blame it on the natural danger of inhibition and pretend like they're otherwise totally functional when not under the influence.
For example, it is unclear how to interpret comparisons between pairwise and clustering ortholog prediction algorithms (e.g., [24]), or between algorithms that predict orthologs and paralogs (e.g., [25]), or how the results should be interpreted when the objective is not functional prediction but phylogenetic inference (e.g., [24]).
The chemical component of the GF-TTMn synapse is therefore not functional when ACh is reduced within the CNS.
If plasma membrane proteins are predominantly endocytosed via clathrin coated pits then one would predict that they should accumulate in the plasma membrane when coated pits are not functional.
When the haematology analysers were not functional, historical platelet counts from previous donations were used.
