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When modification is necessary, the first goal, as stated above, is to maintain viral suppression.
The numerical calculations show that only small modifications are necessary.
Where this occurs major modifications are necessary.
However, modifications are necessary to increase their stability, resulting in some cases in loss of siRNA function [ 28]; there must be a balance between stability and efficacy when modifications are introduced in siRNA.
In the milder and more arid regions along the Mediterranean coast, fewer modifications were necessary.
(The Governor's office said that the modifications were necessary and that the objections were not solely Cuomo's).
Some modifications were necessary.
These modifications were necessary for the circularization of linear TFO.
When the data modification is necessary, we need to select a suitable quantization index.
However, no dosage modification is necessary in patients with renal failure when fentanyl is given as a bolus.
Little modification is necessary to the more regularly divided leaves, and to compound leaves.
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