Sentence examples similar to when it was first demonstrated from inspiring English sources

When ABD1 was first demonstrated to be an essential gene, it was not clear whether this was due to the cap methyltransferase activity of the enzyme or some other hypothetical function of the protein.

Since the 1930s when zinc was first demonstrated to be an integral element of the insulin crystalline structure (1), many studies have been conducted to shed light on the relationship between zinc and insulin action.

When this paradoxical phenomenon was first demonstrated, some authors offered a speculation that it might be due to students experiences related to clinical rotations [7], [19].

When the interferon signature was first demonstrated in SLE, little attention was paid in the field to the immature neutrophil signature that was also described.

This capacity was first demonstrated when it was the first insect shown to have a gene-for-gene interaction with its host plant [ 2].

The synthesis and isolation of 6-phenylethynyl picolinic acid (PEPCA; IUPAC name: 6- 2-phenylethynyl pyridine-2-carboxylic acid) was first demonstrated when Acinetobacter sp. strain F4 was used to biotransform diphenylacetylene to the ring-fission product that underwent facile ring closure to form PEPCA in the presence of ammonium ions.

The importance of APA in cellular differentiation was first demonstrated when Brown and Morrison reported that the immunoglobulins heavy chain (IgH) class shift is triggered by APA (Brown & Morrison, 1989).

The pathogenetic involvement of NO in arthritis was first demonstrated when levels of nitrite, a stable end product of NO metabolism, were shown to be elevated in serum and synovial fluid samples of rheumatoid arthritis patients and osteoarthritis patients [ 6].

The technique was first demonstrated in 2013, when researchers used it to record a 300 KB text file.

The necessity for such modification was first demonstrated by natural rubber (polymer designation cis-polyisoprene) when it began to be produced commercially in the 18th century.

The application of CT to body composition was first demonstrated in 1979 when the cross-sectional area of mid-arm muscle mass was quantified in persons ranging from 60% to 120% of ideal body weight.