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Our findings also support recent reports on SLUG-induced EMT in Madin-Darby canine kidney cells with reduced DDR1 expression when induced to undergo EMT [ 53].
A standard cell culture model of EMT is the immortalized inducible-Twist human mammary epithelial (HMLE-Twist) cell line, which undergoes EMT when induced to express the transcription factor Twist (Mani et al., 2008).
The corrected cystic fibrosis iPSCs, when induced to differentiate in vitro, expressed the corrected CFTR gene; importantly, CFTR correction resulted in restored expression of the mature CFTR glycoprotein and restoration of CFTR chloride channel function in iPSC-derived epithelial cells.
For example, Muse-AT cells demonstrated formation of lipid droplets when induced to differentiate into adipocytes (Figure 4A), as well as characteristic smooth muscle striations when induced to differentiate into myocytes (Figure 4B) [26].
The two chondrocyte populations retained their hypertrophic and non-hypertrophic properties when induced to generate spatially organized proteoglycan-rich cartilage-like tissue in vitro.
ESCs with Dgcr8 or Dicer knockout proliferate at a slower rate, with a slight accumulation of cells in G1 phase, and when induced to differentiate, cannot silence the self-renewal program, suggesting important roles of miRNAs in controlling the self-renewal and differentiation of ESCs (Kanellopoulou et al., 2005; Murchison et al., 2007).
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When experimentally induced to feel compassion by watching a clip about child poverty, upper-class participants behaved just as prosocially toward their partners as did lower-class participants.
However, SRp20 has previously been shown to promote alternative splicing of EDB in fibronectin when induced and to inhibit EDA splicing in chondrocytes [ 26, 47].
Though beneficial and somehow protective when induced prior to insult, the heat shock response paradoxically increases mortality when activated after severe stress.
Moreover, NOX2-deficient mice tend to have more severe joint inflammation when they are induced to develop collagen-induced arthritis when compared with control mice (22).
When Murray felt induced to sell Rangers there was one main problem: few, if any, wanted to buy the club.
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