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Hazard Index: The sum of the hazard quotients when dose addition is assumed.
When dose conversion algorithm was used, the linearity of sensitivity was better about 38%.
For the PARI LC nebulizer, plasma concentration increase was observed when dose increased (for the 1- and 5-mg/kg doses: 0.01 and 0.02 μg/mL).
Kan Wang et al. demonstrated the biocompatibility of GO, which exhibits toxicity to human fibroblast cells when the dose is less than 20 μg/ml but exhibits obvious cytotoxicity when dose is more than 50 μg/ml, with significantly decreasing cell adhesion [32].
Further, oncolysis caused by RGDCRADcox-2R was significant also on C33A and Caski cells when dose of 10 vp/cell was used (Fig. 3a, c).
In most of these studies, when dose is adjusted for species and size of animal, single doses range from about 5 to 50 times higher [1], [10], [18], [60] than the treatment course of P used in the current study.
Similar(11)
The purpose of this was to reduce the impact of desensitization and agonist self-block and to ensure that the slope of all agonist curves was similar when dose-response curves were plotted on double-logarithmic coordinates.
We showed that IR performed better than HE when dose-response data were not obtained under optimal conditions.
In the present study, we present data showing that when dose-dependent effects of dSir2 are taken into account, these many discrepancies can be resolved.
When dose-response patterns are observed in data, they are direct manifestations of the variation in sensitivity and the operation in the population of factors altering that sensitivity.
In summary, IR performed similarly to HE when dose-response data were optimal, whereas IR clearly performed better in suboptimal conditions.
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