People are dispensable when they make your life messy?
However, in the presence of CPT, Cds1 is dispensable when cells restore broken replication forks (Figure 5A).
At promoters where Adr1 primarily recruits coactivators (i.e. ADH2), Cat8 is dispensable when Adr1 is over expressed, despite what is otherwise a strong requirement for Cat8 in terms of expression.
The BRCT motif-containing adaptor protein Crb2, which is required for Chk1 activation is required for checkpoint signaling induced by UV, methyl-methane sulfonate (MMS) and ionizing radiation, but is dispensable when cells are exposed to HU [6], [45].
Consistent with this we show the SIM-interacting domains of both SUMO1 and SUMO2 are required for Pc2-dependent sumoylation of CtBP, but are dispensable when sumoylation is driven by high levels of Ubc9.
Consistently, a seminal study in C. elegans [27], reporting that a functional connection between kri-1, the worm ortholog of KRIT1, and DAF-16, the worm ortholog of mammalian FoxO genes, is required for germline removal-dependent life span extension, has demonstrated that KRI-1 function is dispensable when DAF-16 is unphosphorylated on Akt-consensus sites.
It implies that lpxH2 gene is dispensable when lpxH gene exists.
In these studies, a reaction is considered redundant when it is dispensable in only one or a few conditions.
This suggests that a sizeable proportion of the genes involved in signal transduction and surface structures became dispensable when the Verminephrobacter lineage became symbiotic.
In cell suspensions the PVX movement functions encoded by the TGB and CP genes were dispensable when complemented by the efficient viral cDNA delivery capabilities of A. tumefaciens.
This indicates that the mitochondrial localization is dispensable when death is triggered by stimuli that can directly engage ER localized multidomain proapoptotics.
