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Finally, when discontinuation does occur, there may be value to gradually discontinuing lithium when appropriate, given that gradual discontinuation has been observed to substantially reduce the risk of mood episode relapse [ 56, 57].
For naive infliximab patients, we distinguish three possibilities when discontinuation occurs.
Therefore, when discontinuation of the 2% gel arm was announced the concern about the impact that this would have on relationships and sexual experiences was dominant.
Therefore, patients will be advised to taper down slowly when discontinuation is needed.
Other policies have not been tested prospectively, particularly for treatments alternative to discontinuation, when discontinuation is not possible.
The failure to detect any difference in efficacy between the two treatments in the first 1 or 2 weeks when discontinuation symptoms are likely to be highest suggests that these symptoms did not influence the result.
Similar(51)
Sensitivity analyses showed that the cost-effectiveness of ERN/LRPT 2 g was not affected when a discontinuation rate of 7.4% for ERN/LRPT (the discontinuation rate owing to flushing observed in clinical trials [ 42]) was included in the model.
Endeavor zotarolimus-eluting stents have shorter drug-elution courses, and recent evidence suggests that 3 months of dual antiplatelet therapy appears safe, making Endeavor preferred when early discontinuation of dual antiplatelet therapy is warranted.
Thus, when the discontinuation was announced most women were deeply disappointed as expressed by the following participants: 'We had hope because this gel was something of a high note and we hoped that it (gel) might work and thereafter we could get it from the chemist.
When the discontinuation rate was set to 0% and 4%, the ICERs were £32 494 and £32 315, respectively.
Cutaneous adverse effects are common, with a higher incidence in combination therapy than in IFN alone, and when serious, discontinuation of therapy is mandatory.
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