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The results were virtually the same when deletions were tested instead of amplifications (data not shown).
When deletions were available in both the mat A and mat a mating type backgrounds, the two values were averaged.
For example, WGD will be more parsimonious than PGD if WGD events occur about an order of magnitude less frequently than gene duplications (i.e., with w WGD <0.057) and only when deletions occur in blocks (Fig. 2B).
The MRX complex has many known roles at telomeres, and when deletions are combined with deletions in the Ku complex, the double mutants enter senescence like telomerase-deficient strains (Dubois et al. 2002; Maringele and Lydall 2004a).
Interstitial deletion of 15q11-q13 results in Prader-Willi syndrome (PWS; MIM # 176270) or Angelman syndrome (AS; MIM # 105830), when deletions occur on the paternally-derived or maternally-derived homolog, respectively (see Figure 1; reviewed in refs. [ 2- 4]).
When deletions and duplications at the same locus (polymorphic CNVRs) were combined, there were a total of 14,058 CNVRs, including 7092 deletions, 4885 duplications, and 2081 polymorphic CNVRs (Table 1).
Similar(52)
Moreover, a weak DPA mechanism, coupled with PS, can help to make the network even more heavy-tailed, especially in the limit when deletion and insertion rates are almost equal, and the overall network growth is minimal.
There are other known classes of genetic interactions such as synthetic-sick and synthetic-rescue (when deletion of gene A has a particular phenotype distinct from wildtype, such as slow growth, but deletion of both A and B together results in a strain indistinguishable from wildtype).
The final covariate model was achieved when deletion of each covariate relation was significant.
The algorithm naturally handles certain cases of complex SV events, such as when deletion is accompanied by insertion.
This conclusion was obtained when deletion of ALS3 abrogated C. albicans virulence in the oral epithelial infection model, but not in a bloodstream infection model [ 69, 72].
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