In cases when circulating biotherapeutic is rapidly eliminated from circulation due to the formation of anti-product antibodies, tissue data may provide useful insight on test article exposure at the site of therapeutic action (or at the site of toxicity).
Later, when circulating around the room or saying goodbye at the end of class, you can give specific praise for what you observed.
Susan Harder, founder of the Dark Sky Society of East Hampton, said her group had found wide support when circulating petitions favoring the project.
But when circulating blood cells are killed — by chemotherapy, say — the stem cells awaken and begin to divide with awe-inspiring fecundity, generating millions of cells that gradually mature into blood cells.
"WHEN circulating libraries were first opened," wrote Charles Knight in 1854, "the booksellers were much alarmed; and their rapid increase added to their fears, and led them to think that the sale of books would be much diminished by such libraries.
It is known that CMV can be reactivated when circulating monocytes with latent CMV are recruited to sites of inflammation [20].
When circulating estrogen levels decline as a natural consequence of menopause and aging in women, there is an increased incidence of deficits in working memory.
The potential explanation for these results is that increased E2 concentrations during the periovulatory period can improve pregnancy success and pregnancy maintenance, and this effect appears to be greatest in heat-stressed cows when circulating E2 may be reduced.
Consequently, it seems reasonable to avoid any utilization of vitamin supplements when there is no incontrovertible evidence for insufficiency, and when circulating plasma levels of vitamins remain within the normal range.
Using this battery, we investigated the behavioral impact of acute social defeat stress (ASD) early thereafter (ASD-early, ∼4 h), when circulating corticosterone levels were elevated, and late after stress-induction (ASD-late, ∼8 h), when corticosterone were returned to timed control levels.
Despite the success of testicular removal or suppression, androgen receptor antagonists, and androgen synthesis inhibitors in the treatment of prostate cancer, the sources of androgen, their routes of synthesis, and the contributions of various routes remain topics of debate, particularly in castration-resistant disease when circulating androgens are very low.
