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You need to figure out the job market and the job 'norms.' "Take time to find out what constraints exist at that institution," urges Weingart.
This is the approach where you identify the need, do a rigorous analysis of understanding who else is out there, and what constraints exist, and how you could differentiate yourself in a meaningful way.
However, the recent guidelines ask that proposals report if the current systems will be able to achieve and sustain any planned scale-up of intervention and what constraints exist.
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Although Doña Elisabeth implicated the state and international donor agencies in her discussion of her family's and fellow citizens' health and economic troubles, she also struggled to comply with the expectations she had for herself and others to continue to seek care no matter what constraints might exist.
What affordances and constraints exist in relation to ECS and ECS models, in comparison to a self-contained model? .
In the case of the brain, we currently do no know what constraints on amplification exist.
What has been shown previously for classic gene transfer therapy may obviously work for RNAi-based strategies, too, but strict additional constraints exist for RNAi vector structure to avoid loss of therapeutic efficacy and disturbance of miRNA pathways.
Certainly, law-based constraints exist, but so too do principle-based and other moral constraints (Faden et al. 1986).
Any entrepreneur in a market economy sees his task as making money despite whatever constraints exist.
Other methodological constraints exist.
In addition, the following relative constraints exist.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com