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Although far from allowing conclusions, our study illustrates that we do not as of yet sufficiently understand what constitutes relevant nodal disease.
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However, what constitutes clinically relevant changes in MINICHAL scores is currently undecided.
Rogers' factors and Berwick's rules apply, but the specifics of what constitutes better, relevant, simple, easily tested, visible to others, or the slack necessary for change will all require recalibration for the new context.
It might be interpreted that the limit of what constitutes a "relevant" and a "detectable" change is similar whether it derives from the scores of patients who report improvement or deny it.
Much work remains to be done to more definitively answer questions about when to start therapy, which patients are most likely to benefit, what constitutes clinically relevant beneficial effects over the longer term, and when these drugs are no longer clinically effective.
However, at the same time the Bureau noted that "A number of court decisions over the last several years regarding what constitutes a relevant patent and the time period during which such a patent can be added have somewhat altered the balance contained in the NOC Regulations between the competing interests of the brand name pharmaceutical patent holders and generic drug companies.
There is no agreement as to what constitutes a clinically relevant change in cardiac output.
Fifthly, our definition of what constitutes a clinically relevant study design may be challenged.
In addition, what constitutes a clinically relevant change in scores for symptoms is unclear.
Both researchers and decision-makers need to think broadly about what constitutes appropriate and relevant evidence [ 31, 32].
18 Posterior probabilities may increase our understanding of cardiovascular safety data in this situation and allow for different notions about what constitutes a clinically relevant increase in risk.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com