That report also found that deaths and injuries had occurred as a result of device malfunctions when the stents were used off-label.
A 2008 study in a medical journal, the American Journal of Therapeutics, estimated that one million biliary stents were used off-label from 2003 to 2006 to open clogged blood vessels in other parts of the body.
PH drugs were used off-label in CTEPH.
The recordings were used off-line to re-reference the scalp recordings to the common average.
These EOG signals were used off-line for eye movement correction.
Moreover, the CGM devices in the study were used off-label and were originally designed for outpatients.
A large study in a UK maternity hospital with 17,694 prescriptions in a three-month period found 83% of the medicines prescribed were used off-label with 59% being classified as "caution" or "high risk" for use in pregnancy [ 14].
Moreover, although a wide variety of compounds are used off-label to treat tinnitus patients, there is still no US Food and Drug Administration or European Medicines Agency approved drug on the market.
"Lots of drugs are used off-label, but is this use appropriate?" said Ms. Darnovsky.
Like Khan Academy lectures, the simulations "can be used off-line," said Katherine Perkins, the project's director.
That could give Medicare grounds for denying payment when the drug is used off-label, as cancer drugs often are.
