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The inferred networks were then refined by refinement algorithms with different models of gene duplications and losses.
The solutions of the molecular replacement were then refined in REFMAC5 (18) through rigid body, isotropic, and anisotropic refinements.
These parameters were then refined using a reduced model containing a split-plot error structure.
The glycoside derivative-PfHT complexes were then refined using the hybrid QM/MM (PM3/ff03) method within the AMBER package.
Pilot reports were run for faculty and grad students based on a day in March; these reports were then refined for the May run and include undergrad information.
Evolutionary algorithm runs were performed to locate local minima on the potential energy landscape defined using interatomic potentials, the structures of which were then refined using density functional theory.
Various preliminary data sets were released between 1984 and 1986, and these were then refined several times to produce the final IRAS Sky Survey Atlas, which was published in 1993.
The resulted ten structure-based hypotheses were then refined to essential three point pharmacophore features that captured recurring and crucial non-covalent receptor contacts and proposed three characteristics necessary for optimal zone-2 binding: a conserved pair of H bond acceptor (HBA to form H bond with Asn226 residue) and an aliphatic moiety of molecule separated by 3.75 ± 0.44 Å.
Fields were then refined and validated by experts.
The segmented 50S subunit images were then refined to reconstruct a 3D volume.
The XRD patterns were then refined using the HighScore Plus (PANalytical B.V). and FullProf software packages.
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