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The following covariates were tested: use of salazopyrine, prednisone, methotrexate or biologicals, DAS28, presence of joint erosions, rheumatoid factor (RF) positivity and anti-cyclic citrullinated peptide (anti-CCP) positivity, breast feeding and maternal age at delivery.
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The distributions of all variables were tested using analysis of skewness and kurtosis.
Homogeneity of multivariate dispersions between locations were tested using Permutational Analysis of Multivariate Dispersions (PERMDISP), and were only found to be significant for unweighted UniFrac distance matrices (p < 0.03).
Significant effects of site and time series were tested using analysis of variance (ANOVA).
Mean differences of continuous variables between groups were tested using analysis of variance.
Hierarchical logistic models were tested using data of May 2015.
Changes in lactate over time were tested using analysis of variance (ANOVA) on repeated measurements.
Pairwise interactions between markers were tested using analysis of variance.
Differences among treatment groups were tested using analysis of variance.
Differences between countries were tested using ANOVA of the numerical data.
These were tested using blockers of various ion channels in the plasma membrane.
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CEO of Professional Science Editing for Scientists @ prosciediting.com