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The output files were summarized using a custom Perl script, and regions masked by more than one sequence in the repeat library were recognized and counted only once.
We previously identified or derived a measure for each criterion, and the findings were summarized using a scoring system.
For each study meeting the inclusion criteria, descriptive information related to the country of origin, subject characteristics, sample size, time from injury/surgery to testing, the research protocol, and associated injuries were summarized using a customized Excel (Microsoft, Redmond Washington, USA) spreadsheet.
Image data were summarized using a median-based approach that is described in more detail in the Supplemental Methods S1.
Geographical breed locations (Table S1) were summarized using a Gabriel neighboring graph which models the spatial structure of the breeds (Figure S5).
Trees were summarized using a burning value of 1,000.
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Fracture outcomes of individual trials in men were summarized using an intention-to-treat analysis principle.
Read counts for each gene were summarized using an in-house Perl script.
Next documents were summarized using an abstraction tool and given a relevance score and a scientific validity score, both ranging from 1 to 3. The relevance score ranged from 1 for documents offering a minor or marginal contribution to the understanding of the phenomena studied to 3 for documents providing detailed insights directly focused on those phenomena.
Imaging was summarized using a four-point scale based on the degree of visible detail with higher numbers corresponding to greater detail (Figure 1).
Imaging detail was summarized using a pre-specified 4-point scale based on the degree of visible detail with higher numbers corresponding to greater detail.
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