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Statins may be speculated to increase autoantibody production, thereby facilitating RA development.
For these reasons, FGF21 is speculated to increase longevity by partially mimicking the effect of CR in liver and potentially other tissues.
The reduced activity of the MTHFR C677T polymorphism was speculated to increase the pool of intracellular 5,10-methylene THF, which protects against potential defects in DNA synthesis, although circulating folate levels (5-methyl THF) tended to be lower [ 10].
In Bacillus subtilis, enzymes that catalyze the degradation of branched-chain amino acids are induced during cold shock and are speculated to increase membrane fluidity by promoting the incorporation of branched chain fatty acids into membrane lipids [ 51].
Based on previous observations of considerable activity and limited toxicity of GEM as first-, second- and even third-line treatment in phase II studies of MBC (Seidman, 2003), the addition of GEM to epirubicin and PCX was speculated to increase activity of the combination without additional toxicity.
The beneficial effects of the two coexisting metals were speculated to be increasing the population of CoIV, which are believed to be the active sites for the OER.
The combination of greater hypotension and inadequate tissue blood flow (i.e., hypoperfusion) observed in alcohol-intoxicated animals and the increased gut leak observed in alcohol-intoxicated hemorrhaged animals are speculated to contribute to increased host susceptibility to infection and tissue injury during recovery (Molina et al. 2013).
FMRP deficiency is speculated to lead to increased neuronal excitability and susceptibility to seizures in humans.
Declining B-cell function has also been speculated to explain the increasing incidence with age (10 ).
The 10% increase in lignin content, as observed in the AcBr analysis, correlates with the 44% increase in acid-soluble lignin content, which is speculated to reveal an increase in the hydrolysable capacity of lignin in softwood after the termite chewing process.
Why increased joint load, which is speculated to result from an increase in knee height, either alone or as a percentage of body height, benefits the cartilage of asymptomatic people is unclear.
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