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Fetal stem cells injected into the brains of stroke injured rats were shown to migrate to injured areas.
Endothelial cells and smooth muscle cells were shown to migrate towards the myocardial matrix both in vitro and in vivo, with a significant increase in arteriole formation at 11 days post-injection.
MSCs were shown to migrate to the bladder grafts and differentiate into SMC [ 67].
Effector/memory Foxp3+ Tregs were shown to migrate from the skin towards draining lymph nodes in steady state as well as during inflammation and can return to skin upon antigen exposure 42.
In subsequent studies, dendritic cells expressing IL-4 were shown to migrate to the paws of MHC-matched mice with collagen-induced arthritis and quell disease activity, even in established disease [ 68].
Indeed, leukocytes devoid of receptors that would support adhesion to the extracellular environment were shown to migrate by squeezing and exerting pushing forces perpendicular to the cell boundary [ 55,56].
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Transplanted/injected MSC have been shown to migrate to a variety of organs and tissues; however, sites of inflammation and pathology elicit enhanced MSC homing for tissue remodeling and repair.
In West Africa it was shown to migrate seasonally during the rainy season [8].
Different cell subsets such as monocytes, NK, neutrophils and T cells have been shown to migrate to the brain coincident with the neurological signs of ECM [22], [23].
The proteins are shown to migrate at a molecular weight of 65 kDa since they include the upstream 15 kDa thioredoxin sequence (Figure 5B).
S. pneumoniae was shown to migrate across respiratory epithelial cells by hijacking the host transcytosis pathway for transporting polymeric immunoglobulin receptor (pIgR) across polarized epithelial cell [28].
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