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The use of β blockers in patients with COPD has been a contentious issue since older generations of β blockers were shown to be intolerable by patients with obstructive airways disease, by precipitating bronchoconstriction [ 161], reducing FEV1, or lowering the methylcholine challenge threshold [ 162].
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Several drugs have, however, been shown to effectively reduce attack frequency in some patients, but these drugs are often associated with adverse effects that can be intolerable [7].
After so many centuries of harsh treatment, this was felt to be intolerable.
"I consider this to be intolerable".
And he considers the political right to be intolerable.
I mean, this is just unbearable and it needs to be intolerable".
Pazopanib in combination with BIV-administered ifosfamide turned out to be intolerable.
It is intolerable to be "different".
However, if one thinks that such conclusions are intolerable, how are they to be avoided?
Thumper has to be seen to be in control — anything that threatens the appearance is intolerable.
The headache is moderate to severe in intensity and can be intolerable in some sufferers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com