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The endothelial dysfunction and platelet aggregation responses mediated by reelin were reverted upon treatment of a reelin neutralizing antibody.
These changes were reverted upon CSC differentiation.
Most expression changes in senescence were reverted upon hTERT expression (Fig. 1E).
Furthermore, the Phase II clinical trial for lamotrigine (Na+ channel blocker), on secondary progressive MS patients showed exacerbation in motor function abnormalities, which were reverted upon a reduction in the lamotrigine dose [ 98].
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Circular dichroism (CD) spectra reveal that DNA undergoes important conformational changes upon adsorption onto the core-shell surface, which are reverted upon TMPyP encapsulation.
In line with this assumption we observed that, although the PTEN-knockout PC3 cells showed a modest defect in G2/M checkpoint which is reverted upon AKT inactivation (Supplementary Figure S3), they still show no HR deficiency phenotype5.
However, this differentiation block was reverted upon doxycycline treatment of CombitTA-FUS-DDIT3 MEFs (15 25%) (Figure 2B).
Interestingly, functional anergy of both CMV and LCMV specific, PD-1 positive T cells was shown to be reverted upon blockade of PD-1 with its ligands [20], [27].
We observed that these specific gene expression changes detected in WWOX knockdown cells can be reverted upon WWOX re-expression.
These changes could be reverted upon remyelination, hence, supporting the idea that myelin can influence glutamate homeostasis and demyelination can drive secondary neurodegeneration [ 112].
Most strikingly, the suppression of CTLA-4 alone resulted in an enhanced activation of PLCγ, which appears to be reverted upon the removal of PAG.
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