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MEFs were reprogrammed to iPSCs by exogenously expressing Oct4, Klf4, c-Myc, and Sox2 (OKMS).
When single cells were isolated from a gametophore leaf, over 90% of them were reprogrammed to stem cells with characteristic nuclear expansion.
This led to restoration of dystrophin protein expression in cells from Duchenne patients, including skeletal myoblasts and dermal fibroblasts that were reprogrammed to the myogenic lineage by MyoD.
The Johns Hopkins team grew the brains from five donors' skin cells, which were reprogrammed to become the equivalent of stem cells, and then stimulated toward becoming brain cells.
During the last couple of hundred years, however, as the rate of social change accelerated and we were reprogrammed to believe in progress, everyone acquired a sporting interest in what might be just over the horizon.
When they applied a daily cocktail of synthetic RNAs that code for five classic reprogramming genes to connective tissue cells called fibroblasts, the cells were reprogrammed to embryoniclike cells.
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The ideal shunt has a valve and can be reprogrammed to regulate the drainage.
A fundamental unresolved question is whether terminally differentiated cells can be reprogrammed to pluripotency.
At this point, the iPSCs can be reprogrammed to become many types of cells.
The hope is that ultimately stem cells from adults could be "reprogrammed" to cure diseases.
Scientists are trying to see if adult stem cells can be reprogrammed to produce cells beyond their normal range.
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