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Mutations in each of these domains were reported to impair the inhibition of hEAG1 currents by Ca2+.
Meanwhile, accumulated ROS caused by estrogen deficiency were reported to impair osteogenic differentiation of MSCs and osteoblasts.
STF-31 and close analogues were reported to impair glucose uptake and directly associate with the glucose transporter GLUT1, suggesting that STF-31 acts as a GLUT1 antagonist.
Mutations in PARK2 were reported to impair the E3 ubiquitin ligase activity of parkin [ Shimura et al., 2000], which resulted in insufficient protein clearance and the subsequent formation of protein aggregates.
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Mitochondrial impairment or insufficiency has been reported to impair the efficacy of SCNT [ 52].
Glycyrrhizic acid has been reported to impair hair growth in some studies; however, its underlying mechanism has not yet been investigated.
The coexistence of CAA with AD has been reported to impair cognitive performance more significantly than AD alone, even after adjustments for age, neurofibrillary tangle and amyloid plaque number, and infarctions [33].
Phytotoxic compounds, such as; ammonium ions, fatty acids, and low molecular weight phenolic acids are reported to impair seed germination and root elongation (Delgado 2010; Gómez-Brandón et al. 2008).
A classical substitution at the crux of this angular domain (M64I) has been reported to impair DNA bending but not DNA binding, implying that sharp bending is required for transcriptional activation and testis determination.
A number of viruses have been reported to impair DC maturation [33].
Disruption of MAS has been reported to impair viability and fetal growth in mouse blastocysts [36].
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