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Contact angles observed for the control proteins BSA and MBP (both at the relatively high concentration of 1 mg/mL) were very similar to those for buffer, suggesting that the effects observed for PLUNC were relatively potent and specific to that protein.
Both long- and short-chain alkylphenols were relatively potent in this response, with EP and NP causing responses at the lowest concentration (10−15 M).
In vitro the former two agents were relatively potent inhibitors of growth of murine adenocarcinomas (MACs) with IC50 values < 10 microM, whereas Zileuton was less effective.
Similar(56)
In vitro studies indicated that most of these compounds are relatively potent inhibitors of each enzyme.
Third, this interaction should be achieved at low concentrations, meaning that the substance has to be relatively potent.
However, the best inhibitor in the cell culture model, compound 3624, was relatively potent in the second YopE secretion assays (60% at 10 µM).
Budesonide, dexamethasone and prednisolone are known to be relatively potent, whilst betamethasone is known to be moderately potent.
These compounds are characterized as being relatively potent and selective toward a relatively narrow array of kinase targets.
Upon isolation the active compound was found to be in low abundance, indicating that it was relatively potent.
S1P was relatively potent, causing one-half maximal desensitization of GC-B at concentrations of 5 10 nM.
These studies resulted in the discovery of C646, a small molecule inhibitor of p300/CBP that is relatively potent, specific, and cell permeable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com