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were refractory
adjective
Obstinate and unruly; strongly opposed to something.
Exact(60)
All rIL-25-treated mice were refractory to infection.
But they also noted that hypnotherapy helped "even those whose conditions were refractory to other forms of therapy".
Modified precursor molecules of miR-122 were synthesized that were refractory to cleavage by Dicer.
Both Cyclin A and Cyclin D1 levels were blunted in response to SENP1 in pBABE-G9a cells, whereas G9a4KR cells were refractory (Fig. 3e).
Nine patients were refractory to the pharmacological treatments.
All patients were refractory to anti-TNFα treatments.
Significantly, cells were refractory to the 20% static stretch level when AQP1 expression was increased to near tissue levels.
Her attacks were refractory to sumatriptan, very effective at sea level, but responded to oxygen.
This study cannot distinguish whether or not patients were taking polypharmacy because they were refractory to monotherapy.
All included cases were refractory to standard conservative treatments, such as medications and physical therapies for at least six weeks.
While inclusion criteria did not require cCH to be medically refractory, most of the ultimately enrolled patients were refractory.
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