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The top candidate model structures were refined via minimization to remove steric clashes and optimization of the hydrogen-bond network by means of side chain sampling using the Schrödinger's Maestro Protein Preparation Wizard [ 69].
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In the "design-based research" trajectory we focused on one feature, a web-based Jigsaw activity, in a philosophy of education course, and demonstrated how it was refined via three design iterations.
The design of a cladding pumped, erbium doped, microstructured fiber amplifier is refined via a tailor made computer code which takes into account the transitions of the rare earth ion populations, the electromagnetic power propagation of pump and signal, the secondary ion ion interactions.
In the subsurface layer of the SMAT Cu samples with low strain rates, grains are refined via formation of dislocation cells (DCs), transformation of DC walls into sub-boundaries with small misorientations, and evolution of sub-boundaries into highly misoriented grain boundaries.
(5) The corrected transmission map is refined via the guided filter to get more smooth structure.
The ribose-5-phosphate structure was refined via PHENIX and REFMAC, using NCS constraints, to 2.5 Å resolution, with Rcryst = 0.205 and Rfree = 0.235.
These have been refined via systematic reviews of the effectiveness of interventions for each subgroup that were undertaken by members of the research team, one of which has been published to date [ 20].
In principle, estimates of the parameters in the model for SNP association status given the functional data can be refined via Bayesian updating as part of an association analysis.
Grains were refined by carbides.
The flaws were refined away over time.
Alignments were refined manually.
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CEO of Professional Science Editing for Scientists @ prosciediting.com