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Protein models were refined by rigid body refinement and restrained refinement using Buster.
The structures from the remaining six datasets were refined by 20 cycles of rigid-body refinement followed by 20 cycles of restrained refinement.
The models were refined by several cycles of manual rebuilding with COOT, followed by refinement using REFMAC.
These structures were refined by simulated annealing with CNS (37) using an explicit water refinement protocol (38).
These groups were refined by Galen and later by Avicenna.
The conventions Aeschylus developed were refined by Sophocles, who brought the chorus up to 15 and added a third actor.
While flake and blade tools were developing, core tools were refined by overall chipping to create thinner and more efficient forms.
Grains were refined by carbides.
Their molecular geometries were refined by ab initio minimizations.
Hence, our docking results were refined by MD simulation, improving the accuracy of the model.
Furthermore, the docking results were refined by MD simulations, improving the accuracy of the models.
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