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When applied to homology modeling, solvent-bound membrane protein structures, pockets, and cavities were recapitulated with near-atomic precision even from distant homologs.
Both interactions known to require ADAP phosphorylation, i.e. ADAP-C with SLP-76 and Fyn SH2, were recapitulated with high specificity.
Importantly, the respective phenotypes were recapitulated with multiple morpholinos and could be effectively rescued [ 15].
These results were recapitulated with an additional set of SETD2 wt and mutant ccRCC cells, which repaired 49% (Caki-2) and 31% (RCC-FG2) of the DNA damage in 6 hr.
The analysis was run twice for each method, to find both up- and down-regulated modules; of particular interest was whether the main result of [ 13], of the rerouting of carbon in the Glycolysis/Gluconeogenesis (GLY/GNG) pathway and the TCA cycle, were recapitulated with this metabolic model.
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Furthermore, inhibition of MEK with GDC-0973 can prevent this metabolic tumor resistance signaling, and this too is recapitulated with FDG-PET imaging.
The anti-inflammatory activity of SNA-enriched IVIG has been recapitulated with highly sialylated, recombinant human IgG1-Fc (Anthony et al., 2008a).
Some important properties of discrete-time Gabor frames are recapitulated with an emphasis on tight frames and the relationship to DFT filter banks.
As an alternative, 3D culture model systems exist in which cell-adhesion dependent tissue architecture, heterotypic cell cell interactions and tissue differentiation can be recapitulated with good fidelity.
Finally, transfection of monocytes with the viral protein Zta caused the upregulation of SOCS3, an event that could not be recapitulated with mutated Zta.
Whilst SOCS3 expression could not be recapitulated with mutated Zta, STAT2 phosphorylation was only partly restored following IFNα treatment in this context.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com