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The inhibitory effects on invasion, growth, and proliferation were recapitulated by knocking down SMAD2, but not SMAD3.
Interestingly, these findings were recapitulated by the use of mouse ASCs expressing Firefly Luciferase, suggesting that this finding is not species specific.
While key features of human psoriasis were recapitulated by mouse model phenotypes, points of non-correspondence relative to each other and to human psoriasis were also identified.
These inhibitory effects upon EphA2, AKT, and src were recapitulated by addition of Hsp90α antibody (Figure S2G), supporting the notion that eHsp90 is a critical regulator of these pathways.
B/M treatment resulted in growth arrest, apoptosis and cell differentiation in both AML cell lines and primary AML cells and these actions were recapitulated by treatment with 15d-PGJ2.
Furthermore, these results were recapitulated by vector-mediated overexpression of NANOG.
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e, H-STS cell line master regulators are recapitulated by its xenograft model.
Prevention of CSD outcomes are recapitulated by blocking corticotropin-releasing factor receptor 1 within the LDTg.
The CNOT2-dependent regulation of representative MHC II and further target genes was recapitulated by RT-qPCR experiments (Fig. 5C).
We propose that angiogenic events leading to vascularization can be recapitulated by harnessing the inflammatory responses.
Protection from re-infection was recapitulated by the adoptive transfer of CD8 or CD4 T cells from PMIF RNA immunized hosts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com