Sixty-seven patients (40 girls, mean age ± SD 11.3 ± 1.1, 27 boys mean age ± SD 11.4 ± 0.9) with eighty-nine PDCs were randomized by block randomization method with allocation concealment in consecutive numbers of sealed envelopes.
The patients were randomized by simple randomization method into rosuvastatin and fluvastatin groups.
Participants were randomized by an online random allocation sequence generated by the EMMES Corporation and accessed by the study nurse coordinator.
Investigators were randomized by a centralized randomization procedure (What Health, Brussels, Belgium) to either a benchmarking group or a control group.
The final pool of 134 facilities were randomized by generating a random number to either the intervention (n = 67) or control (n = 67) group.
The two procedures were randomized by a computer-generated random number list.
The resident population of the study area were randomized, by computer aided block randomization at household level, using Random Allocation Software [ 37] to either receive placebo or treatment.
Eligible participants were randomized by a computer-generated block randomization schema.
After recruitment, the pregnant women were randomized by a computer‐generated permuted block randomization table, in blocks of 45 women with allocation rate of 1 : 1 : 1.
After ascertaining eligibility and collection of baseline measures as described below, subjects were randomized by center and gender using block randomization to ensure equal distribution.
Following enrollment, patients were randomized by study staff who accessed an online randomized schedule.
