Exact(6)
These compounds were progressed into potency determination studies using 10-point dilution curves.
Given these results, both 28 and 38 were progressed into in vivo PK studies.
Five promising hit series containing ligands with ligand efficiencies >0.3 kcal mol−1 per heavy atom were progressed into hit series validation.
As a result, 24 samples were progressed into statistical analysis (3 cALD, 3 child controls, 8 cAMN and 10 adult controls) (Table 1).
Following the discovery of promising novel TryS inhibitors, compounds were progressed into a trypanosomal cell proliferation assay and a human cell counter-screen.
These were progressed into EC50 determination in a T. b. brucei proliferation assay and assessed in a MRC5 proliferation assay to provide an early indicator of toxicity to mammalian cells.
Similar(54)
To evaluate if cells were progressing into mitosis and undergoing death via mitotic catastrophe, we utilized nocodazole to trap cells in mitosis following V158411 treatment.
He continued: "It's interesting how she's progressed into using digital technologies, and there are, of course, all these layers of meaning having to do with men's spaces, women's spaces, the role of animals in art.
"He's progressed into this great player.
Biodegradable stents made of metal have recently been progressed into preclinical tests in humans after their first introduction in early 2000s.
INX-08189 has completed investigational new drug enabling studies and has been progressed into human clinical trials for the treatment of chronic HCV infection.
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