10, 17 While the patients and healthy controls included in the present studies were not matched for age or gender, group comparisons of NfL levels for an age-matched subset of participants led to qualitatively similar results, and we are not aware of any reports highlighting gender differences in CSF NfL concentrations.
Moreover, our samples were not matched for age.
However, in most studies the groups were not matched for the magnitude or direction of fragment movement.
As the groups were not matched for age, Kendall's tau correlation coefficients were calculated between age and the primary outcome measures MSAT sum score and RMET sum score within each group separately.
Although both groups were age and gender matched, this difference in the mean baseline NRS scores between the two groups clearly shows that they were not matched for all factors.
Groups were not matched for sex.
Second, patients were not matched for neck circumference.
The case and control subjects were of the same ethnic origin, but were not matched for age or sex.
Additionally, the samples were not matched for potential differences such as handedness, and even differed in age which itself has an effect on brain structure.
In a follow-up study we therefore investigated subjects diagnosed with DCM, but without LMNA mutation (Group 3), and controls which were not matched for age (Group 4).
One study suggested a lower replicative fitness in HIV-1 isolates obtained from patients infected in 2002 2003 compared to isolates from patients infected between 1986–1999 [14], but samples were not matched for time since seroconversion.
