In this regard, our work shows that while both receptors are induced upon 5FU treatment and required for 5FU-induced apoptosis, DR4 is not activated upon non-genotoxic activation of p53 with Nut3, thus revealing important regulatory differences between these two genes in human cells.
In addition, we found that non-treated Ewing's sarcoma cell lines showed almost no activation of cdc42 and cdc42 was not activated upon bFGF stimulation (data not shown).
Although IRS1 and IRS2 are present in the HEK293 cell line, they are not activated upon insulin stimulation (Fantin et al., 1998).
A major difference is that genes involved in stress and pathogen response are not activated upon infection with the evolved virus, suggesting that selection has favored viral strategies to escape from host defenses.
Cdc42 was not activated upon treatment with Angptl3).
In contrast to Burkhart Schraven, he proposed that Lck is not activated upon TCR/CD3 stimulation.
It turned out that FSAP was not activated upon recalcification and that recalcified citrated plasma removed nucleosomes from apoptotic cells as efficiently as serum [ 9, 10].
However, the role of cGAS in natural HIV-1 infection of primary target cells such as macrophages and DCs, which are not activated upon virus entry, and the evasion strategies employed by the virus, have not been investigated in detail.
Activation was specific to DUX4-FL, as caspase-3 was not activated upon BacMam-mediated expression of the short DUX4-S isoform that lacks the C-terminal region of DUX4-FL (Fig. 1I).
Among the members of this family, which also includes the epidermal growth factor receptor (EGFR or ErbB1), ErbB3, ErbB4, Her2 or ErbB2 is homologous to, but distinct from the others, since it is not activated upon ligand binding.
