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The compounds were much less potent on mammalian protein prenyltransferases.
An anti-ADM antibody directed against the N-terminus substantially increased the survival of mice in a CLP model (HR = 0.077 (CI = 0.0189 to 0.315), p = 0.0004), whereas other antibodies with similar affinities but different epitope specificities were much less potent.
Both variants were much less potent inhibitors of fungal growth than RGFRRR.
However, these ligands were much less potent at hGPR17-L.
Still, the phthalates with estrogenic properties were much less potent than estradiol (Harris et al., 1997).
In contrast, the third NPY family member, pancreatic polypeptide (PP), and the metabolite NPY3 36 were much less potent.
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And the ethnic factor was much less potent than in many elections elsewhere.
But the hitters who will bat behind him are much less potent -- as Manager Bob Brenly has ascertained.
It is interesting to note that the 4′-O-methylated analog 15 (IC50 > 40 μM) is much less potent than 16, indicating that this 4′-O-hydroxy group is perhaps important for the anticancer activity of glycosylated podophyllotoxin derivatives.
Importantly, mini-yCD3 was shown to be much less potent in the induction of T-cell proliferation, cytokine release (interferon-γ and interleukin-2) and early activation marker expression on the cell surface (CD69 and CD25) than parental yCD3.
In the presence of purified anticoagulant heparin and derivative, FGF7 has the similar activity as protamine sulfate for reversal of anticoagulant effect, while FGF1 is much less potent than FGF7.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com