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Negative charged γFe2O3 NPs can absorb more antigen protein than positive charged γFe2O3 NPs, but they were less efficiently cross-presented than positive charged NPs.
This indicates that cells depleted of GR were less efficiently arrested in G1/S upon suppression of nestin, compared to treatment with nestin shRNA alone.
Moreover, these results indicate that the remaining Y330 present in ZnT3Y357-372F were less efficiently engaged in dimer formation with other Y330 residue.
Since DSBs as the major cytotoxic lesions caused by bleomycin are preferably repaired by HR [41], we subsequently examined whether Rad51 and Rad52 were less efficiently recruited to an induced DSB in type I survivors.
However, cross-reactive epitopes in the DBL4 domain were less efficiently targeted in all of the animals immunized with the full-length immunogen compared to the DBL4-6 recombinant protein.
Our proteomic analysis indicated that cell cycle regulatory proteins (including Swe1) were less efficiently down-regulated during starvation in vps4∆ mutants.
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In contrast, 5mC deamination generates thymine, which is less efficiently processed by the DNA repair machinery.
We also find, on the marketable securities side, that technology stocks tend to be less efficiently priced than many other securities.
Although the nuclease-driven production of targeted KOs or KIs is simple and fast, HDR-mediated KIs are less efficiently to obtain.
Then, neutral and negatively charged NPs are expected to be less efficiently adsorbed and uptaken by a negatively charged cell membrane22.
Consistent with this, an UNC-45 mutant lacking the UCS loop (UNC-45ΔUCSloop) is less efficiently cleaved by the protease (Supplementary Fig. 5a).
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