Our result was later substantiated by McGettick et al., 2006 [28] who demonstrated two novel signaling molecules (PKCε and TRAM) act upstream of TRIF and, recently, by Kagan et al., 2008 [29] who discovered that the internalization of TLR4 into the endosome is required prior to TRIF-dependent pathway activation.
This proposal was later substantiated by the finding that the water-soluble protein fraction of bovine corneas accounts for only 17% of the total protein but for nearly 50% of the total absorption of UVB-light (290 300 nm), leading to the suggestion that the water-soluble proteins in the cornea be termed absorbins [6].
The first MHCI sequence to be identified in teleosts, a genomic fragment from goldfish (Carassius auratus, GenBank accession AAA72345.1), belonged to the Z lineage [ 6], which was later substantiated as an expressed MHCI lineage [ 32].
The advantage of colour Doppler ultrasound in detecting pseudoaneurysms was reported by Barba et al. [ 9] and was later substantiated by Hoshino et al. [ 10] A history of cholecystitis prompted us to do an ultrasound, which raised the suspicion of a pseudoaneurysm, that was confirmed later on a CECT scan.
"We have found hundreds of incidents of the police using disorderly conduct wrongly against homeless folks," Mr. Miller said, adding that many of those charges were later dismissed or could not be substantiated.
The rumour was later widespread but never substantiated and Ciano's wife, Edda Mussolini, denied it.
This 'two hit' mechanism was first hypothesised by Knudson (Knudson, 1976) and later substantiated following cloning of RB1 (Friend et al, 1986).
Writing about the crash in the New York Times and on his blog, Sharkey defended the American pilots, whom he felt were being scapegoated by Brazilian authorities, and criticized the Brazilian air traffic control system (criticism later substantiated by the U.S. National Transportation Safety Board).
As far as the mechanism is involved, all members of the forum subscribe the hydrodynamic theory firstly suggested by Gysi [ 6] and later substantiated by Brännström [ 7].
While Williams' allegations have not been substantiated, even if they are later proven, his actions certainly cannot be condoned.
