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Since the distribution of the parameters is highly asymmetric close to Z = 0 mm and Z = 10 mm, the tails of the distributions were not considered in the fit, and the asymmetry values corresponding to Z = 0 mm and Z = 10 mm were imposed to be equal to the two limits of the distributions (−1 and 1).
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The corrected values are imposed to be equal to measurements (guess value).
First, the policy effect is imposed to be constant across quarters over the period.
In particular, in [9] and [7], the nonlinear term f is imposed to be nonnegative.
Estimating equation (1) and equation (2), the policy effect is imposed to be constant across quarters over years.
Next, the policy effect is imposed to be constant across quarters within a year, but allowing for variation between years by introducing year specific dummies for the policy period.
As an example, the κ and A parameters in the electrostatic model are imposed to be non-negative.
No time limit was imposed to be consistent with previous methodology [ 7, 12].
In addition, based on previous study,(40) the nucleotide 82 from one pRNA was imposed to be within 1.2 nm from nucleotides 39−41, 49, and 62−64 of the second pRNA of the dimer.
This results in wide (and costly) safety margins having to be imposed, to ensure there is no rapid deterioration.
Instead, more strict conditions should be imposed to ensure local provenances are used.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com