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Most noteworthy, the first CFM-DS isolates with the mosaic PBP 2 XXXIV (n = 2) were identified already in 2001.
Weak, less contributing items, which were identified already in the Mokken analyses, were confirmed in the 2PL GRM analyses.
For example, D53N and Y94H in HA (numbering is based on the protein sequence without the signal peptide) were identified already in influenza A(H3N2) strains circulated in 2009, and their prevalence in the viral population increased up to and through July 2010 and then gradually decreased (numbering of mutations is based on the HA protein without the signal peptide).
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The necessity of a neutron source for fusion materials research was identified already in the 70s.
Thereby, subtle developmental cardiovascular changes can be identified already in fetal or early postnatal life.
Some specific genes that may contribute to these differences in response to exercise have been identified already.
The first reported phage in the species Corynebacterium acnes, a species which largely overlaps with todays' P. acnes, was identified already in 1964 by Brzin [ 35].
The patients in the previous study had been referred to special respiratory clinics and those with airway hyperresponsiveness may have been identified already in primary health care level.
Then we removed all gene phenotype associations that have been identified already and are contained in either MGD or Sanger-MGP to only generate potentially novel links between genes and phenotypes.
All of the 'common' recurrent CNVs in epilepsy (15q13.3, 16p13.11 and 15q11.2) have probably been identified already, given the extent of the array-CGH genome-wide searches already completed [ 33, 34].
This is in contrast to previous observations in patients with PKAN, a different subgroup of NBIA, where a marked reduction of the brain iron content was identified already after 6 months of treatment with deferiprone by R2* relaxometry.
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