Sentence examples for were highly deleterious from inspiring English sources

In addition, mutations disrupting Watson Crick geometry at the adjacent G769 C810 base pair were highly deleterious (36, 37).

In fact, selection could preserve the length of these microsatellites, even those with high rates of expansion and contraction, if length changes were highly deleterious.

Excessive Fe uptake is highly deleterious, as it catalyzes the generation of reactive oxygen species.

And the problem with this is that it creates an extra-legal venue for arbitration that has proven in many investment treaties in recent years to be highly deleterious for basic government regulatory processes and especially around issues of health, safety, environment, and other issues.

We may wish to consider only those mutations that are nonsynonymous, and in particular those that are highly deleterious.

This is expected in populations of highly variable RNA viruses and implies that non-synonymous substitutions can be highly deleterious [68], [69].

Because these changes are highly deleterious in their mitochondrial counterpart and cannot persist in the mitochondrial genome, they must have been gained in the nuclear genome.

It indicates that the ablation of OD is highly deleterious to the cell even when the activity was reduced by a mere 8%.

In addition, distribution of fitness effects in a non-stationary population suggested that at least 30% of the non-synonymous or 16% of all mutations in human nuclear genes are highly deleterious [49].

The consequences of upsetting this balance by increasing the level of DNA damage or by mutational inactivation of DNA repair genes are highly deleterious and result in the development of cancers in humans and in mouse models [8], [9], [10], [11].

States of marked uncoupling are highly deleterious and are associated with increased ROS.