This is likely due to the fact that they are generally lowly expressed, and a deeper sequencing of these samples would likely reveal the remaining parts of these TARs.
CpGs located in open chromatin regions are generally lowly methylated, whereas hypermethylated regions are marked by H3K9me3.
The expression of families of genes implicated in xenobiotic metabolism was detected in a variety of patterns, suggesting that metabolism may occur along the length of the midgut, although polarization of expression of several metabolic gene families was observed, such that they are generally more lowly expressed in the middle midgut.
"It's generally a pretty lowly job and I don't think anyone actively looks forward to working on the gift guide," says one gift-ed-out magazine writer.
These are contrasted with what are generally considered to be more lowly images: blurry pics of celebrities, gummy bears, stock photos of a wine glass all blown up to sizes they were never meant to be.
Beyond the lure of ego -- even the lowliest of Councilmembers is generally better known than all but the crème de la crème of hedge fund managers -- there are great financial incentives for wanting to buy a Council seat.
Second, lowly expressed gene fusion transcripts are generally more difficult to detect if there is insufficient read coverage at the junction site and do not have supporting discordant PE reads.
For this hypothesis to be able to explain the shortness of highly expressed genes, it must be true that highly expressed genes are generally required to be transcribed/translated with higher rates than lowly expressed genes.
Because target encounter occurs by mass action and lowly expressed miRNAs have a less probability to meet target-containing transcripts, an miRNA expressed under a threshold concentration (< 100 copies per cell) is generally considered as noneffective.
Alternatively, default unmethylated sites, such as CpG islands (CGIs) associated with transcription start sites, remained generally lowly methylated (Fig. 1g).
