The generated models were further refined with extensive MD simulations.
The models were further refined by clustering, docking and molecular dynamics (MD) simulation.
To test this hypothesis we generated wt hAID and N51A models, as well as models of their complexes with substrates which were further refined with extensive MD simulations.
A matrix-based approach was used to estimate the rate constants from experimental data and these were further refined using generalized constrained nonlinear optimization.
The single point energies were further refined at the CCSD(T /aug-cc-pVDZ level of T /aug-cc-pVDZn T /aug-cc-pVDZ1G(2d,p) optimized geometries.
These items were further refined through two rounds of content analysis using emergent and a priori coding with 10 judges and 2 experts.
SVs were further refined into five categories: deletions, tandem duplications, distal duplications, inter-chromosomal events and inversions.
The properties were further refined (within acceptable limits) during model calibration and the adopted values are provided in Table 1.
These were brought to bear on the first-generation 300 in 2004 and were further refined for the car's redesign.
In the subsequent search, values of design variables found from the preliminary search were further refined by using a nonlinear searching technique.
The mass estimates were further refined using radial velocity measurements obtained with the HIRES instrument of the Keck 1 telescope.
