In contrast, 2,3-oxidosqualene is not accepted by these catalysts supporting the notion that the current substrates are fully bound by recognition of both terminal functional groups.
A disadvantage of this approach, which has been encountered during VISOR, is that it is limited in application to subsystems that are fully bound by PMU measurements.
The high ratio σ 2/σ 1 for 26:13:0 grade is apparently due to the fact that in sample 2 the part of NA presents in the free form, while in sample 1 NA is fully bound in double salts.
When the gods knew that Fenrir was fully bound, they took a cord called Gelgja (Old Norse "fetter") hanging from Gleipnir, inserted the cord through a large stone slab called Gjöll (Old Norse "scream"), and the gods fastened the stone slab deep into the ground.
In this case, titrated 2-BP was fully bound.
For example, the bundle domain has to be able to rotate when it is fully bound but not when it is bound to only Na+ ion.
where C a M 00 00 are CaM species in apo state, C a M 11 11 is fully bound CaM, and C a M 00 11 and C a M 11 00 are CaM species with fully bound N- and C-terminals, respectively.
While ligand-binding sites are distorted, the domain remains compact, suggesting that it relocates across the membrane as a rigid body, similarly to when it is fully bound (Reyes et al., 2009).
Although the RepD affinity is much higher with ICRIII present, these measurements were carried out at high RepD concentration; therefore, in either case the DNA should be fully bound with RepD.
DOI: http://dx.doi.org/10.7554/eLife.02283.027 The apo transport domains in the outward- and inward-facing states are essentially identical and as compact as when they are fully bound, consistent with previous spectroscopic experiments (Focke et al., 2011).
