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Patients who met any of the criteria (listed above) at the screening visit were excluded from trial participation.
In the AFFIRM trial, patients with a history of seizures or with other risk factors for seizures were excluded from trial entry.
Participants on prescribed long-term oral corticosteroids, suffering from a health condition where adherence to the intervention was contraindicated or improbable, or unlikely to remain in the UK for 3 years, were excluded from trial entry.
A further review of the data indicates that 72% (13/18) of the ineligible breast patients were excluded from trial entry because they had received too much prior treatment.
Other possible selection biases include the following: patients were excluded from trial entry if their treating physician felt that they needed palliative chemotherapy, which potentially limited the study population to patients with slow-growing disease; the median age of our patients was 63 and many had bone-only disease (29%).
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The likelihood that illegally obtained evidence will be excluded from trial provides deterrence against Fourth Amendment violations, and the remote possibility that the subject is a parolee and that the evidence may be admitted at a parole revocation proceeding surely has little, if any, effect on the officers incentives.
Candidates will be excluded from trial entry if any of the following exclusion criteria exist at screening: 1. Known sensitivity to any of the products to be administered.
Based on the results of Trial 1, which showed no effects of DCD on Si uptake in T2 (see Results), DCD was excluded from Trial 2 and N rates were adjusted to 210 kg N ha−1 across all pots.
Historically, they have been completely absent: the thalidomide scandal of the early 1960s resulted in women of childbearing age being excluded from trials.
Nevertheless, until the nineties children kept being excluded from trials just to safeguard their vulnerability [ 4].
There are also implications of the high prevalence of comorbidities to clinical trial design in people with CKD (where people with comorbidities may be excluded from trials).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com