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Parameters were estimated using maximum-likelihood estimation.
Correlations were estimated using a robust bicorrelation mid-weight estimator.
CTF parameters were estimated using CTFFIND435.
Midazolam population pharmacokinetic parameters were estimated using NONMEM.
Turnover rates of orthogroups were estimated using the ML fitting.
Subjective values were estimated using the RL model (Methods).
Single subject effects were estimated using a fixed-effect model.
Costs were estimated using DRG charges.
Crystal grain sizes were estimated using XRD.
Models were estimated using investigator-specified variables and a proprietary risk-adjustment method.
Event rate ratios were estimated using a multivariable negative binomial regression model.
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