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It quickly became clear that the Sudanese government's efforts were escalating from a heavy counterinsurgency to what many international activists and the United States have labeled genocide, as defined by the 1948 Genocide Convention.
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Weekly doses were escalated from 1200 mg/m2 administered intravenously over 120 minutes to 2800 mg/m2 over 280 minutes for three weeks every four weeks.The first-course MTD was 2250 mg/m2.
Doses of continuously administered apatinib were escalated from 250 mg.
Doses were escalated from 17 to 21 Gy.
(days 1-3) at doses that were escalated from 10 to 18 mg kg-1 day-1.
The Cmax and AUC increased as the doses were escalated from 10 to 180 mg m−2.
Both were escalated from 50 mg b.i.d. of dasatinib and 800 mg m−2 of dacarbazine.
Doses were escalated from cohort 1 through cohort 3. The primary objective was to establish the safety and pharmacokinetic profile of olaratumab.
During administration of the conditioning regimen, carboplatin was administered as 200 mg/m/day which translated to AUCs ranging from 2.7 to 4.2 (median=3.24) (Table 1)._Topotecan doses were escalated from 1.5 mg/m/d to 6.0 mg/m/d.
As shown in Table 1, the tested doses were escalated from 300 to 360 mg BID of tivantinib in ARQ 197-003 (EM study) and from 120 to 240 mg BID in ARQ 197-005 (PM study).
The greatest increase in LH was exhibited when doses were escalated from 12.5 to 25 mg, but the 24-h average of total testosterone only increased by 27%, suggesting a dose-limiting effect on the testosterone-producing Leydig cells of the testes, and the inability of enclomiphene citrate to stimulate the production of supernormal levels of testosterone.
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CEO of Professional Science Editing for Scientists @ prosciediting.com