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Gene density plots were created using CViT73.
Boxplots and heatmaps were created using R.
Maps were created using QGIS version 2.18.1 (www.qgis.org).org
Binary files were created using BinarizeBed with the '-peaks' option.
Three mathematical models were created using response surface regression methodology.
Models were created using scikit-learn [45].
Most figures were created using GMT (Wessel and Smith 1991).
Dichotomous variables were created using these continuous substance use variables.
All graphs were created using MINITAB® version 16.1.0 statistical software.
The figures were created using Adobe Photoshop CS graphics program.
Excitation emission matrices (EEMs) were created using FL Solutions software.
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