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The Hamming distance was calculated between kinases based on their binary bioactivity fingerprints (compounds inhibiting kinase activity by 50% or more were considered active and compounds inhibiting kinase activity by less than 50% were considered inactive) and an MDS plot was generated using Orange Canvas [61].
Substrates were considered active if the mean activity of each transformant was greater than or within 2 SDs of the N169-T120/TP15 positive control.
Therefore to enable cross-assay comparison, the top 20% of compounds (by activity or pIC50) were considered active so that every assay would have the same hit rate.
Molecules with activities below the lower threshold were considered inactive, while those with activities above the upper threshold were considered active.
Each bioassay detected activity in 50% of the species that were considered active against the two human cell lines tested.
The older adults who devoted 150 minutes weekly to perform moderate physical activities, or 75 minutes to vigorous physical activity, or an equivalent combination of both, were considered active [ 27].
Similar(11)
Ligands with Ki or IC50 values of 10 μM or lower (195 compounds) were considered actives.
Non-occupational physical activity was considered active when > 2 sessions of 20 minutes per week were performed.
Although there is abundant evidence of the benefits of physical activity, the percentage of individuals who may be considered active is low in our setting [ 12].
When 1 mouse approached and actively contacted another mouse, the mouse's behavior was considered active and the other mouse's behavior was considered passive.
A neuronal connection was considered active when the neuron i was active (according to its activation function).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com