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With bioinformatic analysis of whole-genome cattle-human comparative map and the bovine genome assembly Btau 4.0, totally 13 annotated genes and 2 putative genes were mapped within the previously identified 1.5Mb linkage region on BTA6 (Mei et al., 2009), which were compose of TBC1D1, KLF3, TLR10, TLR1, TLR6, LOC511583, TMEM156, LOC528668, WDR19, LOC514842, LOC514925, RPL9, LIAS and UGDH.
Statistical learning method SVM (support vector machine) was used for predicting allergens since 2006, and the input features of most SVM-based prediction approaches were compose of either amino acid composition or pair-wise sequence similarity score with known allergens' [ 20- 27, 27].
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