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17 Importantly, more breaks in sedentary time were beneficially associated with several of the outcomes.
In contrast, frequent interruptions (breaks) to sedentary time (defined as the transition from sedentary to an active state for ≥1 min) were beneficially associated.
In a population at high risk of type 2 diabetes, the Botnia Dietary Study showed that high dietary intake of α-carotene, β-carotene, and lycopene and high plasma β-carotene concentration were beneficially associated with glucose metabolism in participants (6).
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10 These results suggest that BNP is beneficially associated with obesity and obesity-related metabolic disorders.
We reported that physical activity is beneficially associated with cartilage volume in healthy children [ 11, 12].
We found consistent evidence that IPFP area was beneficially associated with radiographic OA, knee structural abnormalities and pain.
In this regard, epidemiological studies have demonstrated that light physical activity is beneficially associated with postprandial blood glucose concentrations and markers of insulin sensitivity (19, 20).
IPFP maximum area is beneficially associated with radiographic OA, MRI structural pathology and knee pain on a flat surface suggesting a protective role for IPFP possibly through shock absorption.
Our findings propose the possibility that BNP could be increased by daily physical activity and plasma BNP is beneficially associated with insulin resistance.
Recent epidemiologic findings have also shown 2-h plasma glucose to be beneficially associated with objectively measured light-intensity activity (22).
In this case, it may be that sedentary time substitutes light-intensity physical activity [56] that, in turn, has been beneficially associated with health outcomes, such as blood glucose [57].
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