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Nearly all of the bone marrow cells are clonally derived in patients with both MDS and AML developing from MDS, regardless of the myeloblast count. 2 Furthermore, the existence of rare multipotent MDS stem cells was established and all cells identified somatically acquired genetic lesions that were backtracked to distinct MDS stem cells.
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This is far from trivial, but can be successful when some components are re-used in multiple services and if certain errors in the behaviour of the service composition can be backtracked to the originating component.
Thus, both clonal metastasis (Yachida et al. 2010; Wu et al. 2012) and disease recurrence or relapse (Mullighan et al. 2008; Anderson et al. 2011; Clappier et al. 2011) can be backtracked to an earlier origin from minor subclones.
The compartments considered for the benchmark set are the 11 subcellular localizations used in the overview figure, and all evidence for more specific localizations have been backtracked to this level.
The pair of vertices in the above formula is saved as an arc (v m, v n ) of a directed graph (a set of trees, or forest), T P, which can be backtracked to find the path of maximum weight.
In addition, several studies have shown that specific mutations found at diagnosis in children with leukemia were present at birth, that is, "backtracked" to neonatal Guthrie Cards (blood spots used for newborn screens) (reviewed in [ 2]).
"We will be backtracking to those who helped carry out this fraud, and along the way we will be looking closely at anyone who may have helped harbor these fugitives," Mr. Bailey said.
And European officials say Mrs. Merkel is backtracking, unwilling to take the kind of risks now that she contemplated even two months ago, like harsher bank stress tests, a restructuring of Greek debt or even lower interest rates for loans to Ireland and Greece.
At the same time, France appears to be backtracking on a pledge to remove ads from public TV, which was expected to direct more ad revenue to the commercial channels.
To seething local parents, the new administration seemed to be backtracking from its pledge to set aside half of the seats for community children.
THE problem is that African leaders appear to be backtracking on their pledges to deepen democracy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com