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The historical timelines of the selected users were also retrieved using the REST API.

The sequence and map positions of the contigs for 1848 markers were also retrieved using HarvEST barley ver. 1.63.

Furthermore, annotations for all predicted rice MADS-box proteins, QTLs and their associated simple sequence repeat (SSR) primer pairs were also retrieved using Gramene [ 12, 43, 90, 91].

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The following parameters were also retrieved: visual acuity (using Snellen chart assessment), blood pressure (measured with electronic sphygmomanometer), body weight, height, waist hip ratio, HbA1c, lipid profile, fasting glucose, eGFR (MDRD) and spot urine albumin to creatinine ratio (uACR) (all tests performed in accredited government hospitals' laboratories).

The following variables were also retrieved from the database using the latest record prior to cohort entry date: age, gender, smoking status, body mass index (BMI; or imputed BMI using the latest height and weight measurements where BMI data were not recorded), Medical Research Council (MRC) dyspnoea grade and FEV1percentt predicted.

Third, the annotation files were also retrieved from GEO database using the GPL accession number.

Gene name synonyms were also retrieved from NCBI to be used at our website, http://www.interologfinder.org, in order to accept gene names as a query.

If available, the data on BCVA and CRT at 1 year after the initial injection of bevacizumab were also retrieved from medical charts and used for analyses.

Rat and mouse orthologues for the human proteins were also retrieved from InParanoid (29), and by using automated BLAST (80% threshold homology applied).

Structures were also retrieved by blast queries [63] on sequences of Protein Data Bank [67] using the seven representative sequences.

All references provided by expert contacts were also retrieved.

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